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Did you know that approximately 20 million Americans suffer from gallstones? Gallstones and other gallbladder obstructions can cause severe discomfort and sickness, frequently requiring immediate medical intervention. The gallbladder is an internal organ in the upper right abdomen beneath the liver, shaped and sized like a pear. It holds bile, a material the liver produces to help break down fat and absorb minerals and vitamins soluble in fat. Blockages and gallbladder issues can cause unbearable discomfort. This article discusses gallbladder function, common problems, symptoms, treatments, and long-term prognosis.

What is a Gallbladder?

The gallbladder is a 4-inch pear-shaped organ located under the liver in the upper right abdomen. It serves to store liver bile, which breaks down lipids. Usually, bile does not have any side effects on your body. However, obstruction of the bile ducts or disease affecting the gallbladder can cause pain and other problems like inflammation, gallstones, or polyps.

What is Gallbladder Disease?

Gallbladder disease refers to disorders that include inflammation, gallbladder obstruction, infection, or stones. The condition may result in severe discomfort and consequences.

Some factors increase gallbladder disease risk. These include:

  • Eating a high-cholesterol diet
  • Being obese or overweight
  • Old age, particularly over 60
  • Being a woman
  • Having a family history of gallbladder disease
  • Being Native American or Mexican
  • Being pregnant or having recently given birth
  • Taking cholesterol-lowering drugs
  • Losing weight simultaneously (through medications such as Victoza or Mounjaro). 

In addition, gallbladder disease is more prevalent in people with diabetes, sickle cell disease, cirrhosis, and Crohn’s disease.

Regular monitoring of symptoms and risk factors can help identify, diagnose, and treat gallbladder issues early, preventing complications and ensuring the best outcome for patients.

What is Gallbladder Disease?

Common Gallbladder Probalems

Gallbladder issues are common and can result in some implications. Here are a few typical gallbladder problems:


Each year, gallstones—solid deposits that develop in the gallbladder—affect almost 20 million Americans. Obesity, abrupt weight loss, meals heavy in calories, and poor fiber are common causes.

Gallstones can be asymptomatic or it could produce symptoms. Some common symptoms are;

  • Nausea
  • Vomiting
  • Shoulder blade or right shoulder pain
  • Upper right abdomen pain that worsens
  • Abdominal pain below the breastbone


Gallstones block the gallbladder tube, causing bile accumulation and irritation, a condition called Cholecystitis. Symptoms of Cholecystitis include severe upper right or center abdominal pain, back or right shoulder ache, stomach soreness, nausea, vomiting, and fever. Untreated cholecystitis can induce gallbladder rupture, which often requires surgery.

Urinary Polyps

Abnormal tissue growths within the gallbladder lining are known as gallbladder polyps. Few acquire cancer, but most don’t. Gallbladder polyps include Pseudopolyps (caused by cholesterol buildup), inflammatory polyps (linked to persistent gallbladder inflammation), adenomyomatosis (an overgrowth causing gallbladder wall cysts), adenomas (harmless tumors resembling the biliary tract lining), and malignant polyps.

Biliary Colic

A gallstone obstructing the bile duct can result in biliary colic, characterized by dull pain in the middle or upper abdomen. A stone clearing may relieve the pain, lasting up to an hour. The gallbladder may need surgery if the stone persists.

If you experience severe or continuous pain, jaundice, a high fever, or other gallbladder symptoms, seek medical attention. Early detection and treatment can improve gallbladder outcomes and prevent complications.

Five Common Symptoms of a Gallbladder Disease

Symptoms of gallbladder illness can vary from one person to another. It is essential to identify these symptoms to receive prompt medical attention and an early diagnosis. Some of the most common gallbladder disease symptoms include:

• Pain: Upper-right to mid-abdominal pain is the most common gallbladder symptom.
This discomfort might progress to the chest and back and can be mild, moderate, or severe.

• Nausea or Vomiting: Chronic gallbladder illness can cause nausea, vomiting,
acid reflux, and gas.

• Inexplicable fever or chills: Gallbladder infections can cause fever and chills. Gallbladder
infections can be fatal, so get medical care immediately to prevent them from spreading.

• Chronic Diarrhea/Unusual Stools or Urine: Multiple months of increased bowel movements
indicate chronic gallbladder disease. Lighter stool or black urine are also signs of a
gallbladder problem. These changes often indicate bile duct blockage and require medical

• Jaundice: Yellow skin and eyes indicate a gallstone or bile duct obstruction. It means bilirubin,
which the liver excretes as bile, has accumulated. A gallbladder issue is indicated by
jaundice, which needs to be treated right away by a medical expert.

When To See a Doctor?

Gallbladder disease symptoms lasting more than a few hours require immediate medical attention. Long-term symptoms like fever, jaundice, or severe abdomen pain may indicate a significant issue. If abdominal pain makes it hard to sit or find comfort, treat it immediately.

In some situations, the treatment may require you to surgically removal the gallbladder. This is because by the time most patient notices any symptoms of gallbladder disease, the organ is not serving its purpose well and may have to be removed. In such situations where the gallbladder is removed, the gallbladder’s storage role is assumed by the bile ducts.

Most patients do not notice any appreciable changes in their bowel habits following gallbladder ectomy.

When To See a Doctor?

What are the Risk Factors and Causes of Gallbladder Disease?

Although the exact process by which gallstones form is not always known, several factors raise the likelihood that they may occur. Among these risk factors are:

Gender: Gender is a major risk factor for gallstones because women are more likely to get them
compared to men.

Getting Older: Gallstones are more common as people age, especially around 40.

Obesity: Because obesity raises bile cholesterol levels, which can result in stone formation, obese
people are more likely to develop gallstones.

High Blood Pressure: Gallstones can develop due to blood cholesterol levels that are too high.

Using Drugs That Include Estrogen: Gallstone formation may be more likely to occur when taking certain drugs, particularly ones that contain estrogen.

Quick Weight Loss: Gallstones may occur if weight is lost too quickly, mainly through crash diets or GLP-1 medications, such as Ozempic or Wegovy.

Diabetes: Due to bile composition changes, diabetes patients are more likely to develop gallstones.

Pregnancy: Women who are pregnant are more likely to develop gallstones due to hormonal changes and delayed gallbladder emptying.

The following factors raise gallbladder cancer risk, an unusual cause of bile duct obstruction:

  • Gender: Gallbladder cancer is more common in women than males.
  • Age: Gallbladder cancer is more prevalent in older individuals, particularly from age 40.
  • Gallstone History: People with a history of gallstones are more likely to develop gallbladder cancer.
  • Background of Additional Gallbladder Issues: Polyps and infections increase gallbladder cancer risk.

The gallbladder microbiome’s role in gallstones and other gallbladder disorders is also being studied. Some medical researchers have also discovered that Salmonella and Helicobacter may cause gallstones.

How are Gallbladder Problems Diagnosed?

Following a comprehensive examination and evaluation of your symptoms, doctors use several diagnostic techniques to identify gallbladder issues, including the existence of gallstones. Some of these techniques include:

Physical Examination and Medical History

In addition to asking you about your symptoms, your doctor will examine you physically to find any
abdominal soreness or pain.

Blood Examinations

Blood tests can identify elevated bilirubin levels and blocked bile duct waste products. These tests can also detect infection and liver or pancreatic enzyme abnormalities. A high alkaline phosphatase level may indicate bile duct obstruction. 

Abdominal Ultrasound: This non-invasive examination uses sound waves to create images of the gallbladder and surrounding area, detecting gallstones.

CT Scan of the Abdomen: To provide comprehensive images of your gallbladder and bile ducts, a CT scan uses radiation. This can help identify gallbladder problems, including the presence of stones.

MRCP (Magnetic Resonance Pancreatography)

The hepatobiliary and pancreatic systems, which include the liver, gallbladder, bile ducts, pancreas, and pancreatic duct, can be seen in clear detail on an MRCP scan. This scan offers a thorough perspective for diagnosis.

Cholangiopancreatography (ERCP) via endoscopy

Should MRCP reveal obstructions, an ERCP surgery could be carried out. This treatment will require you to be sedated and an endoscope—a long, thin tube—inserted down your throat and into your bile ducts to contain a tiny camera. It is possible to remove stones or blockages, providing a therapeutic as well as diagnostic answer. With these diagnostic techniques, physicians can more precisely diagnose gallbladder issues, enabling the administration of suitable care and therapy according to the diagnosis.

Treatment Options for Gallbladder Problems

Although gallbladder issues are usually treatable, prompt medical attention is frequently required for the best action. Below are treatment options for gallbladder problems.

Watching and Observing

Gallstones without symptoms may not need immediate treatment. In these cases, a doctor will monitor the gallstones to prevent issues.

Antibiotic Treatment

To treat an infection that exists in the gallbladder and stop it from spreading to other areas of the body, antibiotics may be recommended.

Surgery for Gallstone Extraction

In the following circumstances, surgery might be required:

  • Pain and other symptoms associated with gallstones
  • A tumor in the gallbladder is present
  • Bile duct obstruction
  • Emergencies where quick gallbladder removal is necessary – Porcelain gallbladder, a condition where the gallbladder wall becomes hardened

Emergency Removal of the Gallbladder

Emergency cholecystectomy, or removal of the gallbladder, may be required in certain dire circumstances, such as acute gallbladder inflammation or gallbladder rupture, to avoid potentially fatal consequences.

Gallbladder Drainage

Gallbladder draining is a treatment that may be used when surgery is not applicable. This entails putting a catheter directly through the skin into the gallbladder to release pressure and allow stored bile to escape. The particular gallbladder issue, its severity, and the patient’s general health will determine the best course of action. To find the best course of action for efficiently managing gallbladder difficulties, speaking with a healthcare professional is imperative.

Prevention of Gallbladder Issues

Adopting specific lifestyle practices is necessary to prevent gallbladder disorders. There is no specific way to prevent gallstones, but these steps can help:
  • Balanced Diet: Three well-balanced meals daily support digestive health and manage bile production, reducing gallstone risk.
  • Healthy Weight Maintenance: A balanced diet and regular exercise are essential for maintaining a healthy weight. Maintaining a healthy weight and avoiding abrupt weight loss is vital because obesity is a significant gallstone risk factor.
  • Regular Exercise: Regular exercise improves health and may support gallbladder health.
  • Moderate Alcohol Consumption: Maintain appropriate alcohol levels to prevent gallbladder dysfunction and gallstone formation.

Furthermore, as diabetes and high cholesterol raise the incidence of gallstones, addressing these underlying health issues is essential. Proactively addressing these health issues can improve general wellness and gallbladder health.

Written & Reviewed By
The Diet Pens Team

The Diet Pens Team is a dedicated group of healthcare enthusiasts, nutritionists, and local pharmacists committed to providing the latest and most accurate information about diet pens and weight management. Our team combines years of expertise in healthcare and nutrition with a passion for helping individuals achieve their health goals.

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